Coding

Part:BBa_K4990001:Design

Designed by: Dingjian Zhang, Tianle Xue   Group: iGEM23_CPU-CHINA   (2023-08-19)


FK-13


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]


Design Notes

For antimicrobial peptides, they generally exhibit the following characteristics: ① Structurally, they should be cylindrical or helical, maintaining the molecule's hydrophilicity and hydrophobicity in shape. ② They consist of both positively and negatively charged amino acids, hydrophilic and hydrophobic amino acids, and are supplemented with amino acids that readily form helical structures to enhance antimicrobial peptide activity. ③ Increasing the quantity of positively charged and hydrophobic amino acids enhances bactericidal potency and endotoxin resistance.



Source

Sequence found in Genbank https://www.ncbi.nlm.nih.gov/protein/6S6M_A

References